role of beta-arrestins in the activation and targeting of map kinases
| PAG Title | role of beta-arrestins in the activation and targeting of map kinases |
| PAG ID | WAG001245 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The binding of ?arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kise activation complex using ?arrestin as a scaffold, with subsequent activation of a ?arrestin-bound pool of ERK1/2. The receptor?arrestin¿K complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of ?arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by ?arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptiol activation through the ERK-dependent activation of other kises. The model depicts ?arrestin scaffolding of the ERK1/2 MAP kise cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kise cascade by AT1a receptors. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 1,106 |
| Information Content | Rich |
| Other IDs | |
| Base PAG ID | WAG001245 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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